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IMAGING FIELD GUIDE / mri

MRI sequences: T1, T2, FLAIR and diffusion

Learn why the sequence label matters, compare fluid signal, and understand why DWI must be checked against ADC.

By Satvik Tripathi · Source check: 13 October 2026

Open the interactive lab →
Main fieldRF + encodingTissue signal

Conceptual image-formation schematic · not to scale

MRI has more than one image appearance

Magnetic fields, radiofrequency excitation and spatial encoding produce tissue signals. Sequence choices change which tissue properties dominate the image. There is no single universal MRI brightness scale equivalent to CT attenuation.

Build a comparison before a diagnosis

SequenceUseful teaching pattern
T1 weightedCSF usually dark; cerebral white matter relatively brighter than gray matter.
T2 weightedCSF usually bright; fluid-sensitive appearances.
FLAIRT2-weighted imaging with free-fluid/CSF suppression.
DWI + ADCInterpret the diffusion-weighted appearance with its ADC map.

These are introductory patterns. Sequence parameters, field strength, fat suppression, pathology and artifacts can alter appearances. Match anatomy and acquisition labels when comparing a real examination.

FICTIONAL WORKED SCENARIO

A bright focus on DWI

Brightness alone does not establish restricted diffusion. T2 shine-through can contribute. Corresponding low ADC supports restricted diffusion in context; it does not establish a diagnosis by itself.

RSNA review: diffusion concepts and applications

Safety starts before scanning

No ionizing radiation does not mean no hazards. Exact device identification and specified scanning conditions matter for MR Conditional implants. Gadolinium-based contrast, when indicated, requires its own assessment.

FDA guidance for MRI professionals · Contrast materials

A real image to inspect

Axial T2-weighted brain MRI at the lateral ventricles. Ventricular fluid is bright. This is a different source study and slice level from the T1 example.

T2-weighted brain MRI

Axial T2-weighted brain MRI at the lateral ventricles. Ventricular fluid is bright. This is a different source study and slice level from the T1 example.

Novaksean; source crop by Mikael Häggström · CC BY-SA 4.0 · Unchanged

Independent teaching image; not the patient from the fictional scenario.

References & scope

Educational introduction developed with AI assistance. Schematics simplify physics; worked scenarios are fictional. Real images carry their own source and license. This is not a diagnostic viewer, an imaging-ordering tool or independent clinical validation.

Source and scope notes · Image attribution · Suggest a correction